1. What is the Kaiser Permanente Sepsis Risk Calculator?

The Kaiser Permanente Neonatal Sepsis Risk Calculator estimates the probability of early-onset sepsis in newborns based on maternal and neonatal risk factors. It helps guide decisions about antibiotic treatment while minimizing unnecessary interventions.

2. How Does the Calculator Work?

The calculator uses a logistic regression equation:

Where:

• \( b_0 \) — Model intercept
• \( b_i \) — Coefficient for each risk factor
• \( x_i \) — Value of each risk factor

Explanation: The equation converts a linear combination of risk factors into a probability between 0 and 1.

3. Importance of Neonatal Sepsis Risk Assessment

Details: Early-onset sepsis is a serious condition in newborns. Accurate risk assessment helps balance the need for prompt treatment against the risks of unnecessary antibiotic exposure.

4. Using the Calculator

Tips: Enter accurate values for gestational age, maternal temperature, membrane rupture duration, and GBS status. The calculator provides risk per 1000 births.

5. Frequently Asked Questions (FAQ)

Q1: What is considered high risk?
A: Typically >3 per 1000 births is considered elevated risk, but clinical judgment should always be used.

Q2: How accurate is this calculator?
A: The calculator has been validated in large populations but should be used in conjunction with clinical assessment.

Q3: What other factors should be considered?
A: Clinical signs in the newborn, maternal antibiotic treatment, and other risk factors not included in the model.

Q4: Can this be used for preterm infants?
A: The calculator is valid for all gestational ages but may be less accurate at extremes.

Q5: How should the results be interpreted?
A: Results should guide but not replace clinical decision-making. Discuss with pediatric specialists when in doubt.