pKa = -log10(Ka), From Ka to pKa.
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The pKa value is the negative base-10 logarithm of the acid dissociation constant (Ka) of a solution. It quantifies the strength of an acid in solution, with lower pKa values indicating stronger acids.
The calculator uses the pKa equation:
Where:
Explanation: The equation converts the equilibrium constant (Ka) into a more convenient logarithmic scale (pKa).
Details: pKa values are crucial for understanding acid-base chemistry, predicting protonation states of molecules, and designing pharmaceutical compounds.
Tips: Enter the acid dissociation constant (Ka) in mol/L. The value must be positive (Ka > 0).
Q1: What's the difference between Ka and pKa?
A: Ka is the equilibrium constant for acid dissociation, while pKa is its negative logarithm which provides a more convenient scale.
Q2: What are typical pKa values?
A: Strong acids have pKa < 0, weak acids 0-14, and very weak acids >14. Water has pKa of 15.7.
Q3: How does temperature affect pKa?
A: pKa values are temperature-dependent, typically measured at 25°C. Changes can occur at different temperatures.
Q4: Can this calculator handle very small Ka values?
A: Yes, the calculator can process values as small as 10-14 and smaller, though extremely small values may approach floating-point precision limits.
Q5: What's the relationship between pKa and pH?
A: The Henderson-Hasselbalch equation relates pH and pKa: pH = pKa + log([A-]/[HA]).